Oobli secures FDA GRAS approval for new sweet protein

Health & Nutrition

Oobli secures FDA GRAS approval for new sweet protein

Rafaela Sousa

2 October 2025

Oobli secures FDA GRAS approval for new sweet protein

Oobli has received a “no questions” letter from the US Food and Drug Administration (FDA), confirming that its brazzein-54 sweet protein is Generally Recognized as Safe (GRAS) for use in food and beverages.

Brazzein-54, a protein naturally found in the oubli fruit, becomes the third sweet protein on Oobli’s platform to achieve FDA GRAS status, following brazzein-53 and monellin.

Jason Ryder, Oobli's founder and CTO, said: "Oobli is changing the future of sweetness through the use of sweet proteins as a replacement for traditional cane sugar and other alternative sweeteners like aspartame, sucralose, stevia and erythritol".

"The oubli fruit sweet protein is one of several sweet proteins that is derived from fruits primarily found in West Africa and other equatorial environments. Sweet proteins are a class of proteins that deliver a sugar-like sweetness but don't affect blood sugar, insulin or the gut microbiome."

The company said it is the first to receive FDA clearance for use of the oubli fruit sweet protein.

Ali Wing, CEO of Oobli, added: "The 'no questions' letter from the FDA is further testament to the strong potential that sweet proteins have to disrupt our global dependence on sugar and alternative sweeteners".

"The oubli fruit sweet protein can be safely used in a wide range of foods with support from the scientific community and the FDA. It can replace 70% or more of sugar in products such as sodas, teas, baked goods and more, making the opportunities to reduce our sugar consumption virtually endless."

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